Rifampicin induced fatal ventricular tachycardia, a case study.

B. B. Ballal, Renuka Ballal, Divya Chandrasekharan, Pooja Konde, Omkar Ghadge, M.G. Bodhankar

Abstract


Rifampicin is a semisynthetic derivative of the naturally occurring Rifampicin SV. The drug binds with β subunit of bacterial RNA polymerase and in turn inactivates the RNA polymerase enzyme. It is the drug of choice for treating the infections of Mycobacterium spp., Methicillin Resistant Staphylococcus aureus (MRSA) and Methicillin Resistant Coagulase negative Staphylococci (CoNS). Eighty two years old hospitalized male patient was selected for the study. MRSS Staphylococcus aureus and Acinetobacter baumannii were isolated from sputum sample of the patient. He was treated for pyrexia, anorexia and dry cough with chemotherapeutic agents including rifampicin. Therapy of rifampicin induced fatal ventricular tachycardia in the patient. 


Keywords


Rifampicin, Mycobacterium spp., Methicillin Resistant Staphylococcus aureus (MRSA), Methicillin Resistant Coagulase negative Staphylococci (CoNS), MRSS Staphylococcus aureus, Acinetobacter baumannii and ventricular tachycardia, Rifampicin induced cardiomy

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