Prevalence of Depression in Chronic Kidney Disease patients on maintenance haemodialysis

Zahid Bashir, Irfan Haider, Sara Mubeen


Background: There is higher prevalence of depression in chronic kidney disease patients than in general population. This study was carried out to know the prevalence of depression in chronic kidney disease patients on haemodialysis.

Materials and Methods: This cross sectional study was conducted at Nephrology department government teaching hospital Shahdara, affiliated with Fatima Jinnah Medical University/ Sir Ganga Ram hospital, Lahore. After taking informed consent, data was collected from 150 patients of chronic kidney disease on maintenance haemodialysis . Diagnosis of depression was made according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition.

Results: Out of 150 patients, there were 81 (54%) males and 69 (46%) females. Depression was present in 105 (70%) patients of chronic kidney disease on haemodialysis. Depression was found to be more prevalent in age group 36-55 years  p-value 0.001. There was also a significant association of depression in CKD with comorbidities p-value 0.001. There was no significant association of depression among CKD with gender and time since start of dialysis p-value 0.334 and 0.227 respectively.

Conclusion: Majority of chronic kidney disease patients  undergoing  haemodialysis were depressed .


: Chronic kidney disease, Haemodialysis, Depression

Full Text:



Bargman, J.M. and Skorecki, K. (2008) Chronic Kidney Disease. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Eds., Harrison’s Principles of Internal Medicine, Mc Graw Hill, 1761-71.

Coresh J, Byrd-Holt D, Astor BC, Briggs JP, Eggers PW, Lacher DA, et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol. 2005;16:180–8.

Levey AS, Coresh J. Chronic kidney disease. Lancet 2012;379:165–80.

Maaz AA. End Stage Renal Disease: BMJ Clin Evid. 2010; 2010: 2002.

Hosseinpanah F, Kasraei F, Nassiri AA, Azizi F. High prevalence of chronic kidney disease in Iran: a large population-based study. BMC Public Health 2009;9:44.

Fabrazzo M, De Santo MR, Depression in chronic kidney disease. Semin Nephrol 2006;26:56-60.

Al Zaben F, Sehlo MG, Khalifa DA, Al Shohaib S, Shaheen F, Alzaben L, et al. Prospective study of depression among dialysis patients in Saudi Arabia. Int Urol Nephrol. 2015;47:1001–10.

Anees, M., Barki, H., Masood, M., Mumtaz, A. and Kausar, T. (2008) Depression in Hemodialysis Patients. Pakistan Journal of Medical Sciences, 24, 560-65.

Fan L, Sarnak MJ, Tighiouart H, Drew DA, Kantor AL, Lou KV, et al. Depression and all-cause mortality in hemodialysis patients. Am J Nephrol 2014;40:12–8.

Fan L, Sarnak MJ, Tighiouart H, Drew DA, Kantor AL, Lou KV, et al. Depression and all-cause mortality in hemodialysis patients. Am J Nephrol. 2014;40:12–8.

Hung KC, Wu CC, Chen HS, Ma WY, Tseng CF, Yang LK, et al. Serum IL-6, albumin and co-morbidities are closely correlated with symptoms of depression in patients on maintenance haemodialysis. Nephrol Dial Transplant. 2011;26:658–64.

Tanvir S, Butt GD, Taj R. Prevalence of depression and anxiety in chronic kidney disease patients on haemodialysis. Ann. Pak. Inst. Med. Sci. 2013; 9:64-67.

Chilcot, J., Wellsted, D. and Farrington, K. (2008) Screening for Depression While Patients Dialyse: An Evaluation. Nephrology Dialysis Transplantation, 23, 2653-59.

American Psychiatric Association. (1994) Diagnostic and statistical manual of mental disorders (4th ed). Washington DC: American Psychiatric Publishing.

Fukuhara S, Green J, Albert J, Mihara H, Pisoni R, Yamazaki S. Symptoms of depression, prescription of benzodiazepines, and the risk of death in hemodialysis patients in Japan. Kidney Inter 2006;70,1866-72.

Kimmel PL, Peterson RA. Depression in end stage renal disease patients: Tools, correlates, outcome and needs. Semin Dial 2005;1891-97.

Tyrrell J, Pature L, Cadec B, Capezzali E, Poussin G. Older patients undergoing dialysis treatment: cognitive functioning, depressive mood and health related quality of life. Aging and Mental Health 2005;9:374-9.

Nizami A, Abbas S, Aslam F, Minhas FA, Najma N. Relationship between anxiety, depression, psychological well-being and quality of life in diabetic patients having hemodialysis J Pak Psych Society 2005;2:80-4.

Gadit AA. Out-pocket-pocket expenditure for depression among patients attending private community psychiatric clinics in Pakistan. J Mental Health Policy Economics 2004;7:23-8.

Ali BS, Rahbar MH, Naeem S, Tareen AL, Gul A, Samad L. Prevalence of and factors associated with anxiety and depression among women in a lower middle class semi-urban community of Karachi, Pakistan. J Pak Med Assoc 2002;52:513.

Kurella M, Kimmel PL, Young BS, Chertow GM. Suicide in the United States end-stage renal disease program. J Am Soc Nephrol 2005;16:774-81.

Bokhari SS, Samad AH, Hanif S, Hadique S, Cheema MQ, Fazal MA, et al. Prevalence of depression in patients with coronary artery disease in a tertiary care hospital in Pakistan. J Pak Med Assoc 2002;52:436-9.

Depression and Anxiety in Urban Hemodialysis Patients. Daniel Cukor, Jeremy Coplan, Clinton Brown, Steven Friedman, Allyson Cromwell-Smith, Rolf A. Peterson and Paul L. Kimmel: Clin J Am Soc Nephrol 2007;2:484-90.

Mirza I, Jenkins R. Risk factors, prevalence, and treatment of anxiety and depressive disorders in Pakistan: systematic review. BMJ 2004;328:794.

Yousafzai AR, Yoysaf M, Jan M, Badar A. Serum testosterone levels in young male patients with major depression. J Ayub Med Coll 2000;12:31-2.

Anees M , Barki H , Masood M , Ibrahim M , Mumtaz A. DEPRESSION IN HEMODIALYSIS PATIENTS. Pak J Med Sci 2008;24:560-65.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.