Cytokines Interleukin-6 (IL-6) Levels in Mild Ischemic Heart Disease

Muhammad Wajahat, Muhammad Bilal Iqbal, Menaal Amir

Abstract


Abstract:

Objective: To find the incidence of enhanced levels of IL-6 in angina pectoris.

Type of Study: Cross sectional study.

Place and Duration of study: This study was carried out in a duration of 6 months from February 2018 to July 2018 in Punjab Institute of Cardiology Lahore.  

Materials and Methods: The patients presented with chest pain in PIC were studied and both genders were included in the study. The patients were between the ages of 30 to 70 years and had chest pain of shortness of breath. Only those patients were included in the study who were willing to take part in this study and had raised IL-6 levels. Informed consent was taken from all the patients and carefully designed proforma was used to collect the data of the patient. ECG was performed along with cardiac enzymes levels to rule of acute MI. blood sample was taken from the patients and sent to a reliable laboratory for analysis. Value of >5ng/ml was considered as high value. 

Results: A total of 100 cases with angina were included in this study which had 59(59%) males and 41(41%) females. The patients were between the ages of 30 to 70 years with the mean age of 50 years. In 69% of the cases enhanced IL-6 levels were seen and gender difference was insignificant. Patients with diabetes and hypertension had increased IL-6 levels and 20 cases of DM had increased levels of IL-6 while 22 cases of HTN has increased levels.

 

Conclusion: Enhanced IL-6 levels are seen in patients with ischemia of cardiac tissues and the levels are higher in patients who have associated comorbidities like hypertension and diabetes mellitus.


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