Evaluation of Thrombocytopenia Associated with Enormous use of Proton Pump Inhibitors

Ansar Raza Mohsin, Umair Hayat Khan, Bilal Akbar

Abstract


Objective: The main aim of this study was evaluate the thrombocytopenia associated with enormous use of proton pump inhibitors (PPI).

Place and duration of study: This study was carried out in a duration of 10 months from February 2018 to November 2018 in medical department of Mayo Hospital Lahore.

Materials and Methods: A total of 50 patients were selected who were taking PPI for long term and then their blood samples were taken and sent to a reliable laboratory for CBC and look for thrombocytopenia. All these patients had previous history of NSAID's use and had developed gastric ulcers due to it. Informed consent was taken from all the patients or their relatives. Ethical committee approval was taken. A pre-designed proforma was used to collect the data.

Results: A total of 50 patients were selected to collect the data who were using PPI. A minor decrease in white blood cells were seen in all these patients. All the patients were given one prophylactic dose of heparin which could be the cause of thrombocytopenia. The other drug was proton pump inhibitor and PPI were stopped. 2 days after the PPI were stopped the thrombocyte count increased to 99 × 103 /mm 3. Patients had nonspecific gastritis which was revealed upon upper GI endoscopy. No evidence of H.Pylori infection was seen.

Conclusion: It was concluded that while making the differential diagnosis of thrombocytopenia PPI should be kept in mind.

Keywords: Thrombocytopenia, PPI, inhibitors.


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