Comparing various chelation therapies in thalassemia patients

Akif Ali Khan, Shazmeera Urooj, Salman Ahsen


Objective: To compare various chelationtherapies used for thalassemia on basis of efficacy.

Materials and Methods: The study included 80 patients of thalassemia which were divided in two groups, each comprising of 40 patients. Group 1 was administered orally with deferiprone, whereas, group 2 was injected with deferoxamine.

Results: The patients had an average age of of 20.3 ± 4.3 years. Out of 80 patients, 54 (67.5%) were male and 26 (32.5%) were females. The average ferritin was found to be 2645 ± 1260 for all patients, whereas it was 2545 ± 1232 for group 1 and 2822 ± 1235 for group 2. No significant difference was observed for ferritin level in both the groups (p value=0.232). The complications noted for patients included 18.2% IGT, 7.8% DM and 28.7% hypothyroidism for all thalassemia patients.

Conclusion: Both therapies showed equal efficiency in control of iron load in thalassemia patients.

Key Words: Beta-thalassemia, iron chelators, Deferiprone, Deferoxamine

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