Prevalence of Pulmonary Hypertension in patients with Chronic Obstructive Pulmonary Disease.

Zain ul abideen, Larabe Farrukh, Zeeshan Murtaza

Abstract


Objective: The main aim of this study was to find the prevalence of pulmonary hypertension in patients who presented to us with history of chronic obstructive pulmonary disease.

Place and Duration of study: This study was carried out in a duration of 15 months from December 2018 to February 2020 in medical and cardiology departments of Mayo hospital Lahore.

Materials and Methods: A total of 100 patients were selected for this study. Both male and female genders with age greater than 30 years and past history of COPD greater than one year were included in this study. Patients having past history of connective tissue disorders, primary pulmonary hypertension and chronic pulmonary edema were excluded from this study. Those patients were labelled as COPD in which FEV1/FVC ratio was less than 0.70 on the basis of pulmonary function test and they had less than 12% change in FEV1 after bronchodilator therapy. COPD GOLD guidelines were used and patients were divided into different categories and patients of severe and moderate categories were included in our study. Transthoracic echocardiography was used to measure pulmonary artery pressure and pulmonary hypertension was labelled as pressure of more than 25mmHg.

Results: A total of 100 patients with COPD were included in our study. 61.21±12.79 was the mean age. Among these 81 patients were male and all had a history of smoking. Severe form of COPD was seen in 51% patients. Pulmonary hypertension was seen in 40% of the patients. Regarding gender no significant difference was seen (P value 0.54). Patients with history of COPD for more than 5 years which was seen in 36 (53.73%) of the patients had significant p value p=0.001. Similarly high p value p=0.04 was seen in 23 (57.50%) of the patients who has severe form of COPD.

Conclusion: Almost half of the patients with COPD developed pulmonary hypertension and this was the number is higher in patients with history of severe form of COPD for more than 5 years.

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