Evaluation of correlation between severity of Liver disease and Lipid profile: A cross sectional Study

Sundus Shahzad, Vaneeza Mushtaq, Zain ul abideen

Abstract


Objective: The main aim of our study was to evaluate the correlation between severity of liver disease and lipid profile.

Study design: It was a cross sectional type of study.

Place and Duration of Study: This study was carried out in a duration of 12 months from February 2019 to February 2020 in Medical departments Mayo hospital Lahore.

Materials and Methods: A total of 123 patients of either gender with the age greater than 18 years with the diagnosis of chronic liver disease were included in this study. Etiology was taken into account. Correlation between child Pugh class and lipid profile was studied.

Results: 38.01 ± 14.68 years was the mean age of these patients. Among 123 patients with CLD, 85% (104) were male and 15% (19) were female. In Class A, B and C total of 20% (24), (38%) 47 and (42%) 52 were present respectively. Total cholesterol level was 139.08±40.16 mg/dl, 141.30±51.54 mg/dl and 105.81±40.26 mg/dl in class A, B and C respectively. Mean value of low density lipoprotein in class A, B and C was 84.29±35.16 mg/dl, 88.55±48.13 mg/dl, and 76.67±79.19 mg/dl. Mean value of high density lipoprotein in class A, B and C was 34.42±14.67 mg/dl, 29.81±12.82 mg/dl and 21.23±11.73 mg/dl. Mean value of TG in class A, B and C was 109.17±64.04 mg/dl, 116.32±54.99 mg/dl and 90.06±53.35 mg/dl respectively.

 

Conclusion: According to the results of present study higher percentage of male patients as compared female suffering with chronic liver disorder is seen. 51-60 years was the mean age in which most of the patients were seen. Negative relation between child Pugh class and lipid profile was noted.


Keywords


Cirrhosis, lipoproteins, Chronic Liver Disease, CVD

Full Text:

PDF

References


Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodes J, editors. Oxford Textbook of Clinical Hepatology. 2nd Edition Oxford University Press; 1999.

Council G, Assembly G. Global Burden of Liver Disease: A True Burden on Health Sciences and Economies‼. Available from:http://www.worldgastroenterology.o rg/ publications/ e-wgn/ e-wgn-expert-pointof- viewarticles-collection/global-burden-ofliver- disease-atrue-burden-on-healthsciences- and-economies

Lim YS, Kim WR. The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis. 2008;12:733-46.

Schuppan D, Afdhal NH. Liver cirrhosis. The Lancet. 2008;371(9615):838-51.

NayakMaulik S, Shah RM. Study of lipid profile in cirrhotic patients. Nat J Inte Res Med. 2012;3:89-93.

Jiang ZG, Mukamal K, Tapper E, Robson SC, Tsugawa Y. Low LDL-C and high HDLC levels are associated with elevated serum transaminases amongst adults in the United States: a crosssectional study. PloS One. 2014;9(1):e85366.

McBride J, Shero ST, Smith Jr SC, Watson K, Peter WF, Eckel RH, et al. CopiaAutorizada CDR. 2013.

Mandal SK, Sil K, Chatterjee S, Ganguly J, Chatterjee K, Sarkar P, et al. A study on lipid profiles in chronic liver diseases. Nat J Med Res. 2013;3:70-2.

Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients Hepat Mon. 2010;10:285-8.

Sen A, Kumar J, Misra RP, Uddin M, Shukla PC. Lipid profile of patients having nonalcoholic fatty liver disease as per ultrasound findings in north Indian population: A retrospective observational study. J Med

Allied Sci. 2013;3:59.

Warun Kumar MR, Harisha E. Assessment of lipid profile changes with respect to severity of liver dysfunction in cirrhosis of liver. Indian J Basic Appl Med Res. 2015:4:56-63.

Yasmin T, Siddiqui MSI. Study on Lipid Peroxidation and Lipid Profile Status in Patients of Liver Cirrhosis. Intl J Sci Res. 2015;4:2000-2.

Holkar SR, Vaishnav DM, Hivre MD. Serum lipid pattern in patients of liver cirrhosis. Int J AnatPhysiolBiochem. 2014;1:9-12.

Shah SS, Desai HG J Assoc Physicians India. Apolipoprotein deficiency and chronic liver disease. 2001;49:274-8.

Habib A, Mihas AA, Abou-Assi SG, Williams LM, Gavis E, Pandak WM, Heuman DM. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestaticcirrhotics. ClinGastroenterolHepatol. 2005;3:286-91.

He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, et al., The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss. Am J Pathol. 2010;176:2302-8.

Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 2009;10:405-18.

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response elementbinding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl AcadSci USA. 2004;101:7281-6.

Marchesini G, Brizi M, Bianchi G,

Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844-50.

Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115:1343-51.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.